Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor

• Main Authors: Shin, Joon, Harikishore, Amaravadhi, Wong, Chui Fann, Ragunathan, Priya, Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biophysics; Mycobacteria; F-ATP Synthase; Bioenergetics; Oxidative Phosphorylation; ε Enzyme Inhibitor; NMR Spectroscopy
• Online Access: https://hdl.handle.net/10356/162167
• Institution: Nanyang Technological University

Mycobacterium abscessus (Mab) is a nontuberculous mycobacterium of increasing clinical relevance. The rapidly growing opportunistic pathogen is intrinsically multi-drug-resistant and causes difficult-to-cure lung disease. Adenosine triphosphate, generated by the essential F1 FO ATP synthase, is the...