Endothelial-immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease

• Main Authors: Ng, Chun Yi, Lee, Khang Leng, Muthiah, Mark Dhinesh, Wu, Kan Xing, Chioh, Florence Wen Jing, Tan, Konstanze, Soon, Gwyneth Shook Ting, Shabbir, Asim, Loo, Wai Mun, Low, Zun Siong, Chen, Qingfeng, Tan, Nguan Soon, Ng, Huck-Hui, Dan, Yock Young, Cheung, Christine
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Chemokine Ligand-Receptor Interaction; Circulating Endothelial Cells
• Online Access: https://hdl.handle.net/10356/161599
• Institution: Nanyang Technological University

The top cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD) is cardiovascular complications. However, mechanisms of NAFLD-associated vasculopathy remain understudied. Here, we show that blood outgrowth endothelial cells (BOECs) from NAFLD subjects exhibit global transcriptio...