Sweat-resistant silk fibroin-based double network hydrogel adhesives
The adhesion between flexible epidermal sensors and human skin is essential for maintaining the stable functionality of the sensors. However, it is still challenging for epidermal electronic devices to achieve durable adhesion to the surface of the skin, especially under sweaty or humid conditions....
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sg-ntu-dr.10356-1616132023-07-14T16:06:47Z Sweat-resistant silk fibroin-based double network hydrogel adhesives Wang, Jilei Zhang, Nan Tan, Yurong Fu, Fanfan Liu, Gengxin Fang, Yin Zhang, Xin-Xing Liu, Minsu Cheng, Yuan Yu, Jing School of Materials Science and Engineering School of Chemical and Biomedical Engineering Science::Biological sciences::Biochemistry Silk Fibroin Adhesive The adhesion between flexible epidermal sensors and human skin is essential for maintaining the stable functionality of the sensors. However, it is still challenging for epidermal electronic devices to achieve durable adhesion to the surface of the skin, especially under sweaty or humid conditions. Here, we report a silk fibroin - polyacrylamide (SF-PAAm) double network (DN) hydrogel adhesive with excellent biocompatibility, strong and durable adhesion on wet surfaces, and tunable adhesive properties. The hydrophilic PAAm network greatly improves the water retention capability of the DN hydrogel and reduces the β-sheet crystalline content of the SF, leading to excellent adhesive properties of the hydrogel across a wide range of humidity. The SF-PAAm DN hydrogel adhesive can be readily integrated with different epidermal sensor arrays and performs very well in real-time on-body sweat sensing. The SF-PAAm DN hydrogels have great potential for various epidermal healthcare sensors as well as medical adhesives for other medical applications. National Research Foundation (NRF) Submitted/Accepted version J.W., F.F., Y.T., and J.Y. acknowledge the AME programmatic funding scheme of Cyber Physiochemical Interfaces (CPI) project #A18A1b0045 and the Singapore National Research Foundation Fellowship (NRF-NRFF11-2019-0004). X.Z. thanks the support from the Fundamental Research Funds for the Central Universities (DUT21RC(3)030). 2022-09-12T08:36:28Z 2022-09-12T08:36:28Z 2022 Journal Article Wang, J., Zhang, N., Tan, Y., Fu, F., Liu, G., Fang, Y., Zhang, X., Liu, M., Cheng, Y. & Yu, J. (2022). Sweat-resistant silk fibroin-based double network hydrogel adhesives. ACS Applied Materials & Interfaces, 14(19), 21945-21953. https://dx.doi.org/10.1021/acsami.2c02534 1944-8244 https://hdl.handle.net/10356/161613 10.1021/acsami.2c02534 19 14 21945 21953 en A18A1b0045 NRF-NRFF11-2019-0004 ACS Applied Materials & Interfaces This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.2c02534. application/pdf |
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Science::Biological sciences::Biochemistry Silk Fibroin Adhesive Wang, Jilei Zhang, Nan Tan, Yurong Fu, Fanfan Liu, Gengxin Fang, Yin Zhang, Xin-Xing Liu, Minsu Cheng, Yuan Yu, Jing Sweat-resistant silk fibroin-based double network hydrogel adhesives |
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The adhesion between flexible epidermal sensors and human skin is essential for maintaining the stable functionality of the sensors. However, it is still challenging for epidermal electronic devices to achieve durable adhesion to the surface of the skin, especially under sweaty or humid conditions. Here, we report a silk fibroin - polyacrylamide (SF-PAAm) double network (DN) hydrogel adhesive with excellent biocompatibility, strong and durable adhesion on wet surfaces, and tunable adhesive properties. The hydrophilic PAAm network greatly improves the water retention capability of the DN hydrogel and reduces the β-sheet crystalline content of the SF, leading to excellent adhesive properties of the hydrogel across a wide range of humidity. The SF-PAAm DN hydrogel adhesive can be readily integrated with different epidermal sensor arrays and performs very well in real-time on-body sweat sensing. The SF-PAAm DN hydrogels have great potential for various epidermal healthcare sensors as well as medical adhesives for other medical applications. |
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School of Materials Science and Engineering |
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School of Materials Science and Engineering Wang, Jilei Zhang, Nan Tan, Yurong Fu, Fanfan Liu, Gengxin Fang, Yin Zhang, Xin-Xing Liu, Minsu Cheng, Yuan Yu, Jing |
format |
Article |
author |
Wang, Jilei Zhang, Nan Tan, Yurong Fu, Fanfan Liu, Gengxin Fang, Yin Zhang, Xin-Xing Liu, Minsu Cheng, Yuan Yu, Jing |
author_sort |
Wang, Jilei |
title |
Sweat-resistant silk fibroin-based double network hydrogel adhesives |
title_short |
Sweat-resistant silk fibroin-based double network hydrogel adhesives |
title_full |
Sweat-resistant silk fibroin-based double network hydrogel adhesives |
title_fullStr |
Sweat-resistant silk fibroin-based double network hydrogel adhesives |
title_full_unstemmed |
Sweat-resistant silk fibroin-based double network hydrogel adhesives |
title_sort |
sweat-resistant silk fibroin-based double network hydrogel adhesives |
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2022 |
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https://hdl.handle.net/10356/161613 |
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1773551338994532352 |