Microfluidic impedance-deformability cytometry for label-free single neutrophil mechanophenotyping

• Main Authors: Petchakup, Chayakorn, Yang, Haoning, Gong, Lingyan, He, Linwei, Tay, Hui Min, Dalan, Rinkoo, Chung, Aram J., Li, Holden King Ho, Hou, Han Wei
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Mechanical engineering; Science::Medicine; Biophysical Phenotyping; Impedance Cytometry
• Online Access: https://hdl.handle.net/10356/161619
• Institution: Nanyang Technological University

The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in diseases. While advanced image-based biophysical flow cytometers can probe cell deformability at high throughput, it is nontrivial to couple different sensing modalities (e.g., electrical) to measure other cri...