Atomic structure of the regulatory TGS domain of Rel protein from Mycobacterium tuberculosis and its interaction with deacylated tRNA

• Main Authors: Shin, Joon, Singal, Bharti, Grüber, Ardina, Wong, David Meng Kit, Ragunathan, Priya, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Mycobacterium Tuberculosis; NMR Spectroscopy
• Online Access: https://hdl.handle.net/10356/161762
• Institution: Nanyang Technological University

The stringent response is critical for the survival of Mycobacterium tuberculosis (Mtb) under nutrient starvation. The mechanism is mediated by a GTP pyrophosphokinase known as Rel, containing N-terminal synthetase and hydrolase domains and C-terminal regulatory domains, which include the TGS domain...