Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

• Main Authors: Sun, Yue, Lau, Sze Yi, Lim, Zhi Wei, Chang, Shi Chieh, Ghadessy, Farid, Partridge, Anthony, Miserez, Ali
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Endosomes; Macromolecular Substances
• Online Access: https://hdl.handle.net/10356/161877
• Institution: Nanyang Technological University

Biomacromolecules are highly promising therapeutic modalities to treat various diseases. However, they suffer from poor cellular membrane permeability, limiting their access to intracellular targets. Strategies to overcome this challenge often employ nanoscale carriers that can get trapped in endoso...