Comparing environmental impacts of direct compaction versus wet granulation tableting methods for drugs with poor flowability by life cycle assessment

• Main Authors: Hadinoto, Kunn, Tran, The-Thien, Chua, Angeline, Cheow, Wean Sin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Life Cycle Analysis; Sustainable Production
• Online Access: https://hdl.handle.net/10356/161920
• Institution: Nanyang Technological University

Pharmaceutical tablet productions by direct compaction (DC) are more environmentally sustainable than wet granulation (WG) owed to DC's lower energy consumption. For drug particles with poor flowability, however, the environmental benefits of DC become questionable because DC of such drugs requ...