Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment

• Main Authors: Wu, Guanghao, Zhang, Jinfeng, Zhao, Qianru, Zhuang, Wanru, Ding, Jingjing, Zhang, Chi, Gao, Haijun, Pang, Dai-Wen, Pu, Kanyi, Xie, Hai-Yan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Biosynthesis; Exosomes
• Online Access: https://hdl.handle.net/10356/162027
• Institution: Nanyang Technological University

Atherosclerosis (AS) is a major contributor to cardiovascular diseases worldwide, and alleviating inflammation is a promising strategy for AS treatment. Here, we report molecularly engineered M2 macrophage-derived exosomes (M2 Exo) with inflammation-tropism and anti-inflammatory capabilities for AS...