Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy
Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-ba...
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sg-ntu-dr.10356-1620572023-06-21T07:54:06Z Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy Chen, Yun He, Peiying Jana, Deblin Wang, Dongdong Wang, Menghao Yu, Peiyuan Zhu, Wei Zhao, Yanli School of Physical and Mathematical Sciences School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Cancer Treatment Glutathione Depletion Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic and photothermal properties as well as the ability to perturb redox homeostasis to potentiate immunogenicity and immune responsiveness. OMAs, assembled from charge-transfer complexes and characterized by a broad substrate scope, high accessibility, and flexibly tuned optical properties, demonstrate strong phototherapeutic and adjuvant abilities via the depletion of glutathione and cysteine, and subsequently elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. Furthermore, programmed cell death protein 1 antibody can be employed to synergize with OMAs to suppress tumor immune evasion and ultimately improve the treatment outcomes. This study unlocks new paradigms to provide a versatile OMA-based scaffold for future practical applications. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version This work was supported by the National Natural Science Foundation of China (21972047), Guangdong Provincial Pearl River Talents Program (2019QN01Y314), Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318), Natural Science Foundation of Guangdong Province China (2021A1515010724), China Postdoctoral Science Foundation (2021M691063), Fundamental Research Funds for the Central Universities of China, Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081), and Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). 2022-10-03T03:54:56Z 2022-10-03T03:54:56Z 2022 Journal Article Chen, Y., He, P., Jana, D., Wang, D., Wang, M., Yu, P., Zhu, W. & Zhao, Y. (2022). Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy. Advanced Materials, 34(21), 2201706-. https://dx.doi.org/10.1002/adma.202201706 0935-9648 https://hdl.handle.net/10356/162057 10.1002/adma.202201706 35357041 2-s2.0-85128606570 21 34 2201706 en A20E5c0081 NRF-NRFI2018-03 Advanced Materials © 2022 Wiley-VCH GmbH. All rights reserved. This is the peer reviewed version of the following article: Chen, Y., He, P., Jana, D., Wang, D., Wang, M., Yu, P., Zhu, W. & Zhao, Y. (2022). Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy. Advanced Materials, 34(21), 2201706-, which has been published in final form at https://doi.org/10.1002/adma.202201706. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
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Science::Chemistry Cancer Treatment Glutathione Depletion Chen, Yun He, Peiying Jana, Deblin Wang, Dongdong Wang, Menghao Yu, Peiyuan Zhu, Wei Zhao, Yanli Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
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Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic and photothermal properties as well as the ability to perturb redox homeostasis to potentiate immunogenicity and immune responsiveness. OMAs, assembled from charge-transfer complexes and characterized by a broad substrate scope, high accessibility, and flexibly tuned optical properties, demonstrate strong phototherapeutic and adjuvant abilities via the depletion of glutathione and cysteine, and subsequently elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. Furthermore, programmed cell death protein 1 antibody can be employed to synergize with OMAs to suppress tumor immune evasion and ultimately improve the treatment outcomes. This study unlocks new paradigms to provide a versatile OMA-based scaffold for future practical applications. |
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School of Physical and Mathematical Sciences |
author_facet |
School of Physical and Mathematical Sciences Chen, Yun He, Peiying Jana, Deblin Wang, Dongdong Wang, Menghao Yu, Peiyuan Zhu, Wei Zhao, Yanli |
format |
Article |
author |
Chen, Yun He, Peiying Jana, Deblin Wang, Dongdong Wang, Menghao Yu, Peiyuan Zhu, Wei Zhao, Yanli |
author_sort |
Chen, Yun |
title |
Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
title_short |
Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
title_full |
Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
title_fullStr |
Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
title_full_unstemmed |
Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy |
title_sort |
glutathione-depleting organic metal adjuvants for effective nir-ii photothermal immunotherapy |
publishDate |
2022 |
url |
https://hdl.handle.net/10356/162057 |
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1772826414400143360 |