Mechanistic insights into the membrane fouling mechanism during ultrafiltration of high-concentration proteins via in-situ electrical impedance spectroscopy (EIS)

• Main Authors: Tanudjaja, Henry Jonathan, Ng, Angie Qi Qi, Chew, Jia Wei
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Membrane Fouling; High-Concentration Proteins
• Online Access: https://hdl.handle.net/10356/162121
• Institution: Nanyang Technological University

Membrane fouling by the high protein concentrations used in the biopharmaceutical industry remains poorly understood. In this study, feed concentrations of up to 10,000 ppm of bovine serum albumin (BSA) were investigated with three polymeric membranes, two of which had the same molecular weight cut-...