Harnessing GLUT1-targeted pro-oxidant ascorbate for synergistic phototherapeutics

• Main Authors: Koo, Seyoung, Lee, Min-Goo, Sharma, Amit, Li, Mingle, Zhang, Xingcai, Pu, Kanyi, Chi, Sung-Gil, Kim, Jong Seung
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Ascorbate; Phototherapeutics
• Online Access: https://hdl.handle.net/10356/162217
• Institution: Nanyang Technological University

Despite extensive efforts to realize effective photodynamic therapy (PDT), there is still a lack of therapeutic approaches concisely structured to mitigate the major obstacles of PDT in clinical applications. Herein, we report a molecular strategy exploiting ascorbate chemistry to enhance the effica...