Biomolecule-interactive flexible light emitting capacitor display

Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitti...

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Main Authors: Qi, Xiaoying, Wu, Ruige, Lok, Boon Keng, Kerk, Wai Tat, Lai, Steve Foo Khuen, Fan, Wei, Pu, Kanyi
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/162259
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1622592022-10-11T04:51:17Z Biomolecule-interactive flexible light emitting capacitor display Qi, Xiaoying Wu, Ruige Lok, Boon Keng Kerk, Wai Tat Lai, Steve Foo Khuen Fan, Wei Pu, Kanyi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Biomolecules Liquid Electrodes Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitting capacitor (LEC) display (BIO-LEC) capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence (EL) emission is reported. BIO-LEC comprises a coplanar LEC light source at the bottom, and a designed microfluidic chip as sampling compartment at the top. The quantitative measurement feature of BIO-LEC is achieved by introducing the top liquid electrode, which possesses a unique long dielectric realization time, in the microfluidic chip. BIO-LEC is novel for the following reasons, 1) simple stimuli response principle based on correlating EL intensity to dielectric properties of the top liquid electrode; 2) simple test conditions whereby no labeling is required in the analyte solution to optically detect biomolecules; 3) effective sampling method through the design of an integrated microfluidic chip for hosting the top liquid electrode, ensuring good reproducibility and preventing contamination; 4) sensitive detection limit for heparin concentrations at clinically relevant levels, and 5) high compliance with industrial manufacturing standards. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) X.Q. thanks A*STAR SIMTech RPE funding (C18-A-037). K.P. thanks Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19), Academic Research Fund Tier 2 (MOE2018-T2-2-042), and *STAR SERC AME Programmatic Fund (SERC A18A8b0059) for the financial support. 2022-10-11T04:51:16Z 2022-10-11T04:51:16Z 2022 Journal Article Qi, X., Wu, R., Lok, B. K., Kerk, W. T., Lai, S. F. K., Fan, W. & Pu, K. (2022). Biomolecule-interactive flexible light emitting capacitor display. Small, 18(4), e2103541-. https://dx.doi.org/10.1002/smll.202103541 1613-6810 https://hdl.handle.net/10356/162259 10.1002/smll.202103541 34841654 2-s2.0-85120084421 4 18 e2103541 en 2019-T1-002-045 RG125/19 MOE2018-T2-2-042 SERC A18A8b0059 Small © 2021 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering
Biomolecules
Liquid Electrodes
spellingShingle Engineering::Chemical engineering
Biomolecules
Liquid Electrodes
Qi, Xiaoying
Wu, Ruige
Lok, Boon Keng
Kerk, Wai Tat
Lai, Steve Foo Khuen
Fan, Wei
Pu, Kanyi
Biomolecule-interactive flexible light emitting capacitor display
description Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitting capacitor (LEC) display (BIO-LEC) capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence (EL) emission is reported. BIO-LEC comprises a coplanar LEC light source at the bottom, and a designed microfluidic chip as sampling compartment at the top. The quantitative measurement feature of BIO-LEC is achieved by introducing the top liquid electrode, which possesses a unique long dielectric realization time, in the microfluidic chip. BIO-LEC is novel for the following reasons, 1) simple stimuli response principle based on correlating EL intensity to dielectric properties of the top liquid electrode; 2) simple test conditions whereby no labeling is required in the analyte solution to optically detect biomolecules; 3) effective sampling method through the design of an integrated microfluidic chip for hosting the top liquid electrode, ensuring good reproducibility and preventing contamination; 4) sensitive detection limit for heparin concentrations at clinically relevant levels, and 5) high compliance with industrial manufacturing standards.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Qi, Xiaoying
Wu, Ruige
Lok, Boon Keng
Kerk, Wai Tat
Lai, Steve Foo Khuen
Fan, Wei
Pu, Kanyi
format Article
author Qi, Xiaoying
Wu, Ruige
Lok, Boon Keng
Kerk, Wai Tat
Lai, Steve Foo Khuen
Fan, Wei
Pu, Kanyi
author_sort Qi, Xiaoying
title Biomolecule-interactive flexible light emitting capacitor display
title_short Biomolecule-interactive flexible light emitting capacitor display
title_full Biomolecule-interactive flexible light emitting capacitor display
title_fullStr Biomolecule-interactive flexible light emitting capacitor display
title_full_unstemmed Biomolecule-interactive flexible light emitting capacitor display
title_sort biomolecule-interactive flexible light emitting capacitor display
publishDate 2022
url https://hdl.handle.net/10356/162259
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