Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities

Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbit...

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Main Authors: Shi, Yuzhi, Wu, Yongfeng, Chin, Lip Ke, Li, Zhenyu, Liu, Jingquan, Chen, Mu Ku, Wang, Shubo, Zhang, Yi, Liu, Patricia Yang, Zhou, Xiaohong, Cai, Hong, Jin, Wanzhen, Yu, Yefeng, Yu, Ruozhen, Huang, Wei, Yap, Peng Huat, Xiao, Limin, Ser, Wee, Nguyen, Thi Thanh Binh, Lin, Yu-Tsung, Wu, Pin Chieh, Liao, Jiayan, Wang, Fan, Chan, C.T., Kivshar, Yuri, Tsai, Din Ping, Liu, Ai Qun
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/162290
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1622902022-10-12T01:49:40Z Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities Shi, Yuzhi Wu, Yongfeng Chin, Lip Ke Li, Zhenyu Liu, Jingquan Chen, Mu Ku Wang, Shubo Zhang, Yi Liu, Patricia Yang Zhou, Xiaohong Cai, Hong Jin, Wanzhen Yu, Yefeng Yu, Ruozhen Huang, Wei Yap, Peng Huat Xiao, Limin Ser, Wee Nguyen, Thi Thanh Binh Lin, Yu-Tsung Wu, Pin Chieh Liao, Jiayan Wang, Fan Chan, C.T. Kivshar, Yuri Tsai, Din Ping Liu, Ai Qun School of Electrical and Electronic Engineering School of Mechanical and Aerospace Engineering Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Engineering::Electrical and electronic engineering All-Dielectric Nanocavities Multifunctional Virus Manipulation Chip Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level. Ministry of Education (MOE) National Research Foundation (NRF) Y.S. acknowledges the support from the startup funding in Shanghai Jiao Tong University, No. WH220403019. Y.S. and A.Q.L. acknowledge the Singapore National Research Foundation under the Competitive Research Program (NRFCRP13-2014-01), the Singapore Ministry of Education (MOE) Tier 3 grant (MOE2017-T3-1-001). D.P.T. acknowledges the support from the UGC/RGC of HKSAR, China (Project No. AoE/P-502/20) and Shenzhen Science and Technology Innovation Commission Grant (No. SGDX2019081623281169). P.C.W. acknowledges the support from the Ministry of Science and Technology (MOST), Taiwan (Grant number: 107-2923-M-006-004-MY3; 108-2112-M-006-021-MY3; 110-2124-M-006-004), and in part from the Higher Education Sprout Project of the Ministry of Education (MOE) to the Headquarters of University Advancement at National Cheng Kung University (NCKU). P.C.W. also acknowledges the support from the Ministry of Education (Yushan Young Scholar Program), Taiwan. Y.K. acknowledges a support from the Australian Research Council (grant DP210101292). 2022-10-12T01:49:40Z 2022-10-12T01:49:40Z 2022 Journal Article Shi, Y., Wu, Y., Chin, L. K., Li, Z., Liu, J., Chen, M. K., Wang, S., Zhang, Y., Liu, P. Y., Zhou, X., Cai, H., Jin, W., Yu, Y., Yu, R., Huang, W., Yap, P. H., Xiao, L., Ser, W., Nguyen, T. T. B., ...Liu, A. Q. (2022). Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities. Laser and Photonics Reviews, 16(5), 2100197-. https://dx.doi.org/10.1002/lpor.202100197 1863-8880 https://hdl.handle.net/10356/162290 10.1002/lpor.202100197 2-s2.0-85125436265 5 16 2100197 en NRFCRP13-2014-01 MOE2017-T3-1-001 Laser and Photonics Reviews © 2022 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Engineering::Electrical and electronic engineering
All-Dielectric Nanocavities
Multifunctional Virus Manipulation Chip
spellingShingle Science::Medicine
Engineering::Electrical and electronic engineering
All-Dielectric Nanocavities
Multifunctional Virus Manipulation Chip
Shi, Yuzhi
Wu, Yongfeng
Chin, Lip Ke
Li, Zhenyu
Liu, Jingquan
Chen, Mu Ku
Wang, Shubo
Zhang, Yi
Liu, Patricia Yang
Zhou, Xiaohong
Cai, Hong
Jin, Wanzhen
Yu, Yefeng
Yu, Ruozhen
Huang, Wei
Yap, Peng Huat
Xiao, Limin
Ser, Wee
Nguyen, Thi Thanh Binh
Lin, Yu-Tsung
Wu, Pin Chieh
Liao, Jiayan
Wang, Fan
Chan, C.T.
Kivshar, Yuri
Tsai, Din Ping
Liu, Ai Qun
Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
description Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Shi, Yuzhi
Wu, Yongfeng
Chin, Lip Ke
Li, Zhenyu
Liu, Jingquan
Chen, Mu Ku
Wang, Shubo
Zhang, Yi
Liu, Patricia Yang
Zhou, Xiaohong
Cai, Hong
Jin, Wanzhen
Yu, Yefeng
Yu, Ruozhen
Huang, Wei
Yap, Peng Huat
Xiao, Limin
Ser, Wee
Nguyen, Thi Thanh Binh
Lin, Yu-Tsung
Wu, Pin Chieh
Liao, Jiayan
Wang, Fan
Chan, C.T.
Kivshar, Yuri
Tsai, Din Ping
Liu, Ai Qun
format Article
author Shi, Yuzhi
Wu, Yongfeng
Chin, Lip Ke
Li, Zhenyu
Liu, Jingquan
Chen, Mu Ku
Wang, Shubo
Zhang, Yi
Liu, Patricia Yang
Zhou, Xiaohong
Cai, Hong
Jin, Wanzhen
Yu, Yefeng
Yu, Ruozhen
Huang, Wei
Yap, Peng Huat
Xiao, Limin
Ser, Wee
Nguyen, Thi Thanh Binh
Lin, Yu-Tsung
Wu, Pin Chieh
Liao, Jiayan
Wang, Fan
Chan, C.T.
Kivshar, Yuri
Tsai, Din Ping
Liu, Ai Qun
author_sort Shi, Yuzhi
title Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
title_short Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
title_full Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
title_fullStr Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
title_full_unstemmed Multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
title_sort multifunctional virus manipulation with large-scale arrays of all-dielectric resonant nanocavities
publishDate 2022
url https://hdl.handle.net/10356/162290
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