Bioinspired and biomimetic delivery platforms for cancer vaccines

Cancer vaccines aim at eliciting tumor-specific responses for the immune system to identify and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer vaccines can potentially induce long-term immunological memory for antitumor responses, preventing metastasis and canc...

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Main Authors: Liu, Jing, Liew, Si Si, Wang, Jun, Pu, Kanyi
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/162310
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1623102022-10-13T02:05:23Z Bioinspired and biomimetic delivery platforms for cancer vaccines Liu, Jing Liew, Si Si Wang, Jun Pu, Kanyi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Biomimetic Materials Cancer Immunotherapy, Cancer vaccines aim at eliciting tumor-specific responses for the immune system to identify and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer vaccines can potentially induce long-term immunological memory for antitumor responses, preventing metastasis and cancer recurrence, thus presenting an attractive treatment option in cancer immunotherapy. However, clinical efficacy of cancer vaccines has remained low due to longstanding challenges, such as poor immunogenicity, immunosuppressive tumor microenvironment, tumor heterogeneity, inappropriate immune tolerance, and systemic toxicity. Recently, bioinspired materials and biomimetic technologies have emerged to play a part in reshaping the field of cancer nanomedicine. By mimicking desirable chemical and biological properties in nature, bioinspired engineering of cancer vaccine delivery platforms can effectively transport therapeutic cargos to tumor sites, amplify antigen and adjuvant bioactivities, and enable spatiotemporal control and on-demand immunoactivation. As such, integration of biomimetic designs into delivery platforms for cancer vaccines can enhance efficacy while retaining good safety profiles, which contributes to expediting the clinical translation of cancer vaccines. Recent advances in bioinspired delivery platforms for cancer vaccines, existing obstacles faced, as well as insights and future directions for the field are discussed here. Ministry of Education (MOE) K.P. thanks the Ministry of Education Singapore, Academic Research Fund Tier 1 (2019-T1-002-045 RG125/19 and RT05/20), Academic Research Fund Tier 2 (MOE2018-T2-2-042), A*STAR SERC AME Programmatic Fund (SERC A18A8b0059), the National Key R&D Program of China (2017YFA0205600), the National Natural Science Foundation of China (51633008), the Science and Technology Program of Guangzhou (007306355061), Guangdong Provincial Pearl River Talents Program (2017GC010713), the China Postdoctoral Science Foundation (2019M662933), and the Natural Science Foundation of Guangdong Province, China (No. 2021A1515010592, 2019A1515011926) for the financial support 2022-10-12T08:29:51Z 2022-10-12T08:29:51Z 2022 Journal Article Liu, J., Liew, S. S., Wang, J. & Pu, K. (2022). Bioinspired and biomimetic delivery platforms for cancer vaccines. Advanced Materials, 34(1), e2103790-. https://dx.doi.org/10.1002/adma.202103790 0935-9648 https://hdl.handle.net/10356/162310 10.1002/adma.202103790 34651344 2-s2.0-85116999065 1 34 e2103790 en 2019-T1-002-04 RG125/1 RT05/20 MOE2018-T2-2-042 ERC A18A8b0059 Advanced Materials © 2021 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering
Biomimetic Materials
Cancer Immunotherapy,
spellingShingle Engineering::Chemical engineering
Biomimetic Materials
Cancer Immunotherapy,
Liu, Jing
Liew, Si Si
Wang, Jun
Pu, Kanyi
Bioinspired and biomimetic delivery platforms for cancer vaccines
description Cancer vaccines aim at eliciting tumor-specific responses for the immune system to identify and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer vaccines can potentially induce long-term immunological memory for antitumor responses, preventing metastasis and cancer recurrence, thus presenting an attractive treatment option in cancer immunotherapy. However, clinical efficacy of cancer vaccines has remained low due to longstanding challenges, such as poor immunogenicity, immunosuppressive tumor microenvironment, tumor heterogeneity, inappropriate immune tolerance, and systemic toxicity. Recently, bioinspired materials and biomimetic technologies have emerged to play a part in reshaping the field of cancer nanomedicine. By mimicking desirable chemical and biological properties in nature, bioinspired engineering of cancer vaccine delivery platforms can effectively transport therapeutic cargos to tumor sites, amplify antigen and adjuvant bioactivities, and enable spatiotemporal control and on-demand immunoactivation. As such, integration of biomimetic designs into delivery platforms for cancer vaccines can enhance efficacy while retaining good safety profiles, which contributes to expediting the clinical translation of cancer vaccines. Recent advances in bioinspired delivery platforms for cancer vaccines, existing obstacles faced, as well as insights and future directions for the field are discussed here.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Liu, Jing
Liew, Si Si
Wang, Jun
Pu, Kanyi
format Article
author Liu, Jing
Liew, Si Si
Wang, Jun
Pu, Kanyi
author_sort Liu, Jing
title Bioinspired and biomimetic delivery platforms for cancer vaccines
title_short Bioinspired and biomimetic delivery platforms for cancer vaccines
title_full Bioinspired and biomimetic delivery platforms for cancer vaccines
title_fullStr Bioinspired and biomimetic delivery platforms for cancer vaccines
title_full_unstemmed Bioinspired and biomimetic delivery platforms for cancer vaccines
title_sort bioinspired and biomimetic delivery platforms for cancer vaccines
publishDate 2022
url https://hdl.handle.net/10356/162310
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