Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing

• Main Authors: Wee, Jonathan Wei Kiat, Low, Zun Siong, Ooi, Chin Kiat, Henategala, Benjamin Patrana, Lim, Ridley Zhi Guang, Yip, Yun Sheng, Vos, Marcus Ivan Gerard, Tan, William Wei Ren, Cheng, Hong Sheng, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Angiopoietin related Protein 4; Chemokine Receptor CCR2
• Online Access: https://hdl.handle.net/10356/162357
• Institution: Nanyang Technological University

The persistent inflammatory response at the wound site is a cardinal feature of nonhealing wounds. Prolonged neutrophil presence in the wound site due to failed clearance by reduced monocyte-derived macrophages delays the transition from the inflammatory to the proliferative phase of wound healing....