Slit-Robo signalling establishes a sphingosine-1-phosphate gradient to polarise fin mesenchyme

• Main Authors: Mahabaleshwar, Harsha, Asharani, P. V., Loo, Tricia Yi, Koh, Shze Yung, Pitman, Melissa R., Kwok, Samuel, Ma, Jiajia, Hu, Bo, Lin, Fang, Li Lok, Xue, Pitson, Stuart M., Saunders, Timothy E., Carney, Tom J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Mesenchyme; Robo
• Online Access: https://hdl.handle.net/10356/162458
• Institution: Nanyang Technological University

Immigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces between these cells essential for fin and limb morphogenesis. Morphogens derived from the apical domain of the fin, orientate limb mesenchyme cell polarity, migration, division...