Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice

• Main Authors: Suo, Miaomiao, Rommelfanger, Megan K., Chen, Yulin, Amro, Elias Moris, Han, Bing, Chen, Zhiyang, Szafranski, Karol, Chakkarappan, Sundaram Reddy, Boehm, Bernhard Otto, MacLean, Adam L., Rudolph, K. Lenhard
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Aerobic Metabolism; RNA Binding Protein
• Online Access: https://hdl.handle.net/10356/162482
• Institution: Nanyang Technological University

Increasing evidence links metabolism, protein synthesis, and growth signaling to impairments in the function of hematopoietic stem and progenitor cells (HSPCs) during aging. The Lin28b/Hmga2 pathway controls tissue development, and the postnatal downregulation of this pathway limits the self-renewal...