Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

• المؤلفون الرئيسيون: Mansouri, Farangis, Patiny, Luc, Ortiz, Daniel, Menin, Laure, Davey, Curtis Alexander, Mohammadi, Fakhrossadat, Dyson, Paul J.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Cisplatin; Mass Spectrometry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/162720

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corresponding to segments of H2A and H2B histone...