Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

• Main Authors: Mansouri, Farangis, Patiny, Luc, Ortiz, Daniel, Menin, Laure, Davey, Curtis Alexander, Mohammadi, Fakhrossadat, Dyson, Paul J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Cisplatin; Mass Spectrometry
• Online Access: https://hdl.handle.net/10356/162720
• Institution: Nanyang Technological University

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corresponding to segments of H2A and H2B histone...