Talin and kindlin : batman and robin of Mac1 integrin activation?

• Main Author: Henni Djunaidi.
• Other Authors: Tan Suet Mien
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: http://hdl.handle.net/10356/16284
• Institution: Nanyang Technological University

Macrophage 1 (Mac1) integrin is a leukocyte-restricted adhesion molecule highly expressed on phagocytes and is essential in the development of immune responses. In a normal physiological condition, activation of Mac1 is initiated via inside-out signaling. The final common step of inside-out signalin...