The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis
Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overal...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/162891 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-162891 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1628912023-12-29T06:47:43Z The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis Tan, Wilson Yao, Xinwen Le, Thu-Thao Tan, Anna C. S. Cheung, Carol Y. Chin, Calvin Woon Loong Schmetterer, Leopold Chua, Jacqueline School of Chemical and Biomedical Engineering Singapore Eye Research Institute Duke-NUS Medical School SERI-NTU Advanced Ocular Engineering Science::Medicine Hypertension Blood Pressure Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls. Methods: We conducted a literature search through a search of electronic databases to identify studies before 19 June 2021, which compared OCTA parameters in non-diabetic participants with systemic hypertension vs. controls. If the OCTA parameter had a minimum number of 3 studies that analyzed it, the mean difference between participants with systemic hypertension and controls were analyzed using a random-effects model. Results: We identified 11 eligible studies. At the macula, 9 studies analyzed vessel density at the superficial capillary plexus (SVD), 7 analyzed vessel density at the deep capillary plexus (DVD), and 6 analyzed the area of the superficial foveal avascular zone (FAZ). Participants with systemic hypertension had significantly lower SVD (standardized mean difference [SMD], -0.50 [-0.70, -0.30], P < 0.00001, I 2 = 63%), lower DVD (SMD, -0.38 [-0.64, -0.13], P = 0.004, I 2 = 67%) and larger superficial FAZ (SMD, 0.32 [0.04, 0.61], P = 0.020, I 2 = 77%). Conclusion: The eyes of people with systemic hypertension have robustly lower superficial and deep vascular densities at the macula when compared to control eyes. Our results suggest that OCTA can provide information about pre-clinical microvascular changes from systemic hypertension. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University National Medical Research Council (NMRC) Published version Funding received for this work from the Duke-NUS Medical School (Duke-NUS-KP(Coll)/2018/0009A), the National Medical Research Council (CG/C010A/2017; OFIRG/0048/2017; OFLCG/004c/2018; TA/MOH-000249-00/2018 and MOHOFIRG20nov-0014), National Research Foundation Singapore (NRF2019-THE002-0006 and NRF-CRP24-2020-0001), A∗ STAR (A20H4b0141), the Singapore Eye Research Institute & Nanyang Technological University (SERI-NTU Advanced Ocular Engineering (STANCE) Program), and the SERI-Lee Foundation (LF1019-1) Singapore. 2022-11-11T07:33:40Z 2022-11-11T07:33:40Z 2021 Journal Article Tan, W., Yao, X., Le, T., Tan, A. C. S., Cheung, C. Y., Chin, C. W. L., Schmetterer, L. & Chua, J. (2021). The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis. Frontiers in Medicine, 8, 778330-. https://dx.doi.org/10.3389/fmed.2021.778330 2296-858X https://hdl.handle.net/10356/162891 10.3389/fmed.2021.778330 34859021 2-s2.0-85119843476 8 778330 en Duke-NUS-KP(Coll)/2018/0009A CG/C010A/2017 OFIRG/0048/2017 OFLCG/004c/2018 TA/MOH-000249-00/2018 MOH-OFIRG20nov-0014 NRF2019-THE002-0006 NRF-CRP24-2020-0001 A20H4b0141 LF1019-1 Frontiers in Medicine © 2021 Tan, Yao, Le, Tan, Cheung, Chin, Schmetterer and Chua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Science::Medicine Hypertension Blood Pressure |
spellingShingle |
Science::Medicine Hypertension Blood Pressure Tan, Wilson Yao, Xinwen Le, Thu-Thao Tan, Anna C. S. Cheung, Carol Y. Chin, Calvin Woon Loong Schmetterer, Leopold Chua, Jacqueline The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
description |
Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls. Methods: We conducted a literature search through a search of electronic databases to identify studies before 19 June 2021, which compared OCTA parameters in non-diabetic participants with systemic hypertension vs. controls. If the OCTA parameter had a minimum number of 3 studies that analyzed it, the mean difference between participants with systemic hypertension and controls were analyzed using a random-effects model. Results: We identified 11 eligible studies. At the macula, 9 studies analyzed vessel density at the superficial capillary plexus (SVD), 7 analyzed vessel density at the deep capillary plexus (DVD), and 6 analyzed the area of the superficial foveal avascular zone (FAZ). Participants with systemic hypertension had significantly lower SVD (standardized mean difference [SMD], -0.50 [-0.70, -0.30], P < 0.00001, I 2 = 63%), lower DVD (SMD, -0.38 [-0.64, -0.13], P = 0.004, I 2 = 67%) and larger superficial FAZ (SMD, 0.32 [0.04, 0.61], P = 0.020, I 2 = 77%). Conclusion: The eyes of people with systemic hypertension have robustly lower superficial and deep vascular densities at the macula when compared to control eyes. Our results suggest that OCTA can provide information about pre-clinical microvascular changes from systemic hypertension. |
author2 |
School of Chemical and Biomedical Engineering |
author_facet |
School of Chemical and Biomedical Engineering Tan, Wilson Yao, Xinwen Le, Thu-Thao Tan, Anna C. S. Cheung, Carol Y. Chin, Calvin Woon Loong Schmetterer, Leopold Chua, Jacqueline |
format |
Article |
author |
Tan, Wilson Yao, Xinwen Le, Thu-Thao Tan, Anna C. S. Cheung, Carol Y. Chin, Calvin Woon Loong Schmetterer, Leopold Chua, Jacqueline |
author_sort |
Tan, Wilson |
title |
The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
title_short |
The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
title_full |
The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
title_fullStr |
The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
title_full_unstemmed |
The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
title_sort |
application of optical coherence tomography angiography in systemic hypertension: a meta-analysis |
publishDate |
2022 |
url |
https://hdl.handle.net/10356/162891 |
_version_ |
1787136525716160512 |