Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

• Main Authors: Stsiapanava, Alena, Xu, Chenrui, Nishio, Shunsuke, Han, Ling, Yamakawa, Nao, Carroni, Marta, Tunyasuvunakool, Kathryn, Jumper, John, de Sanctis, Daniele, Wu, Bin, Jovine, Luca
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Cryo-EM; Structure Refinement
• Online Access: https://hdl.handle.net/10356/162976
• Institution: Nanyang Technological University

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy...