Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification

• Main Authors: Chan, Hung, Li, Qing, Wang, Xiansong, Liu, Wing Yingzhi, Hu, Wei, Zeng, Judeng, Xie, Chuan, Kwong, Thomas Ngai Yeung, Ho, Idy Hiu Ting, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Ko, Ho, Chan, Raphael Chiu Yeung, Ip, Margaret, Gin, Tony, Cheng, Alfred Sze Lok, Zhang, Lin, Chan, Matthew Tak Vai, Wong, Sunny Hei, Wu, William Ka Kei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Autophagic Flux; Clostridium Difficile
• Online Access: https://hdl.handle.net/10356/162981
• Institution: Nanyang Technological University

Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB is a major C. difficile exotoxin that activates macrophages to promote inflammation and epithelial damage. Lysosome impairment is a known trigger for inflammation. Herein, we hypothesize that TcdB could impair ma...