HAMLET particles in medium : protein fibrils or something else?

• Main Author: Ng, Nicholas Kwok Hing.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/16300
• Institution: Nanyang Technological University

HAMLET, a complex of unfolded α-lactalbumin and oleic acid, kills tumour cells but spares differentiated cells. As HAMLET is a potential anti-cancer drug, mechanism of toxicity needs to be addressed. The HAMLET complex consists of partially unfolded α-lactalbumin with oleic acid and unfolded protein...