Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

• Main Authors: Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Intermittent Fasting; DNA Methylation
• Online Access: https://hdl.handle.net/10356/163083
• Institution: Nanyang Technological University

Objective: Vascular dementia (VaD) is the second most common cause of dementia worldwide. The increasing contribution of lifestyle-associated risk factors to VaD has pointed towards gene-environment interactions (i.e. epigenetics). This study thus aims to investigate the DNA methylation landscape in...