Ionic regulation of mycobacterial infection by potassium and potassium channel

• المؤلف الرئيسي: Lim, Carey Fang Hui
• مؤلفون آخرون: -
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2022
• الموضوعات: Science::Biological sciences::Microbiology::Immunology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163110
• المؤسسة: Nanyang Technological University

Epigenetic analysis of monocytes from active TB patients demonstrated enrichment of KCNJ15, which encodes an inwardly rectifying K+ channel (Kir4.2). We investigated the function of Kir4.2 in mycobacterial infection using a gain and loss-of-function approach and knockout mouse model. Kir4.2 was obse...