Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

• Main Authors: Krah, Alexander, Grüber, Gerhard, Bond, Peter. J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biophysics; Mycobacteria; F-ATP Synthase; Diarylquinolines; Bedaquiline; TBAJ-876; Molecular Dynamics Simulations
• Online Access: https://hdl.handle.net/10356/163131
• Institution: Nanyang Technological University

Tuberculosis (TB), the deadly disease caused by Mycobacterium tuberculosis (Mtb), kills more people worldwide than any other bacterial infectious disease. There has been a recent resurgence of TB drug discovery activities, resulting in the identification of a number of novel enzyme inhibitors. Many...