Sex difference in tDCS current mediated by changes in cortical anatomy: a study across young, middle and older adults

The observed variability in the effects of transcranial direct current stimulation (tDCS) is influenced by the amount of current reaching the targeted region-of-interest (ROI). Age and sex might affect current density at target ROI due to their impact on cortical anatomy. The present tDCS simulation...

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Bibliographic Details
Main Authors: Bhattacharjee, Sagarika, Kashyap, Rajan, Goodwill, Alicia M., O'Brien, Beth Ann, Rapp, Brenda, Oishi, Kenichi, Desmond, John E., Chen, Annabel Shen-Hsing
Other Authors: School of Social Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163239
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Institution: Nanyang Technological University
Language: English
Description
Summary:The observed variability in the effects of transcranial direct current stimulation (tDCS) is influenced by the amount of current reaching the targeted region-of-interest (ROI). Age and sex might affect current density at target ROI due to their impact on cortical anatomy. The present tDCS simulation study investigates the effects of cortical anatomical parameters (volumes, dimension, and torque) on simulated tDCS current density in healthy young, middle-aged, and older males and females.