How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?

• Main Authors: Reid, Lauren M., Guzzetti, Ileana, Svensson, Tor, Carlsson, Anna-Carin, Su, Wu, Leek, Tomas, von Sydow, Lena, Czechtizky, Werngard, Miljak, Marija, Verma, Chandra, De Maria, Leonardo, Essex, Jonathan W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Conformational Ensemble; Proteolipids
• Online Access: https://hdl.handle.net/10356/163258
• Institution: Nanyang Technological University

Understanding the conformational ensembles of intrinsically disordered proteins and peptides (IDPs) in their various biological environments is essential for understanding their mechanisms and functional roles in the proteome, leading to a greater knowledge of, and potential treatments for, a broad...