Do P2Y12 receptor inhibitors prescribed poststroke modify the risk of cognitive disorder or dementia? Protocol for a target trial using multiple national Swedish registries

• Main Authors: Hinwood, Madeleine, Nyberg, Jenny, Leigh, Lucy, Gustavsson, Sara, Attia, John, Oldmeadow, Christopher, Ilicic, Marina, Linden, Thomas, Åberg, N. David, Levi, Chris, Spratt, Neil, Carey, Leeanne M., Pollack, Michael, Johnson, Sarah J., Kuhn, Georg Hans, Walker, Frederick R., Nilsson, Michael
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Cohort Analysis; Dementia
• Online Access: https://hdl.handle.net/10356/163263
• Institution: Nanyang Technological University

Introduction: The target of a class of antiplatelet medicines, P2Y12R inhibitors, exists both on platelets and on brain immune cells (microglia). This protocol aims to describe a causal (based on a counterfactual model) approach for analysing whether P2Y12R inhibitors prescribed for secondary preven...