Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds

This study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L = PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds. Compound 1 (loading: 5 – 10 mol%) was shown to be an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield = 97 %...

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Main Authors: Lee, Jiawen, Fan, Jun, Koh, An-Ping, Cheang, Joslyn Wan-Jun, Yang, Ming-Chung, Su, Ming-Der, So, Cheuk-Wai
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163350
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1633502023-02-28T20:09:16Z Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds Lee, Jiawen Fan, Jun Koh, An-Ping Cheang, Joslyn Wan-Jun Yang, Ming-Chung Su, Ming-Der So, Cheuk-Wai School of Physical and Mathematical Sciences Science::Chemistry Carbene Homologues Carbonyl Ligands This study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L = PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds. Compound 1 (loading: 5 – 10 mol%) was shown to be an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield = 97 %, average TOF = 8.8 h-1) and ketones (average yield = 97 %, average TOF = 1.7 h-1) with pinacolborane (HBpin) in C6D6 at 90 oC to form borate esters. Mechanistic studies shows that the Si lone pair electrons on 1 and the B vacant p orbital of HBpin activates the C=O double bond of aldehydes and ketones, the intermediates of which undergoes hydroboration to yield borate esters and regenerate compound 1. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version This work is supported by the National Research Foundation Singapore, NRF-ANR (NRF2018-NRF-ANR026 Si-POP) and Ministry of Education Singapore, AcRF Tier 2 (MOE2019-T2-2-129) for the financial support (C.-W.S.). M.-C. Yang and M.-D. Su acknowledge the Ministry of Science and Technology of Taiwan for the financial support. 2022-12-09T08:19:30Z 2022-12-09T08:19:30Z 2022 Journal Article Lee, J., Fan, J., Koh, A., Cheang, J. W., Yang, M., Su, M. & So, C. (2022). Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds. European Journal of Inorganic Chemistry, 2022(19), e202200129-. https://dx.doi.org/10.1002/ejic.202200129 1434-1948 https://hdl.handle.net/10356/163350 10.1002/ejic.202200129 2-s2.0-85131822407 19 2022 e202200129 en NRF2018-NRF-ANR026 Si-POP MOE2019-T2-2-129 European Journal of Inorganic Chemistry © 2022 Wiley-VCH Verlag GmbH. All rights reserved. This is the peer reviewed version of the following article: Lee, J., Fan, J., Koh, A., Cheang, J. W., Yang, M., Su, M. & So, C. (2022). Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds. European Journal of Inorganic Chemistry, 2022(19), e202200129-, which has been published in final form at https://doi.org/10.1002/ejic.202200129. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Carbene Homologues
Carbonyl Ligands
spellingShingle Science::Chemistry
Carbene Homologues
Carbonyl Ligands
Lee, Jiawen
Fan, Jun
Koh, An-Ping
Cheang, Joslyn Wan-Jun
Yang, Ming-Chung
Su, Ming-Der
So, Cheuk-Wai
Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
description This study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L = PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds. Compound 1 (loading: 5 – 10 mol%) was shown to be an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield = 97 %, average TOF = 8.8 h-1) and ketones (average yield = 97 %, average TOF = 1.7 h-1) with pinacolborane (HBpin) in C6D6 at 90 oC to form borate esters. Mechanistic studies shows that the Si lone pair electrons on 1 and the B vacant p orbital of HBpin activates the C=O double bond of aldehydes and ketones, the intermediates of which undergoes hydroboration to yield borate esters and regenerate compound 1.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Lee, Jiawen
Fan, Jun
Koh, An-Ping
Cheang, Joslyn Wan-Jun
Yang, Ming-Chung
Su, Ming-Der
So, Cheuk-Wai
format Article
author Lee, Jiawen
Fan, Jun
Koh, An-Ping
Cheang, Joslyn Wan-Jun
Yang, Ming-Chung
Su, Ming-Der
So, Cheuk-Wai
author_sort Lee, Jiawen
title Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
title_short Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
title_full Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
title_fullStr Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
title_full_unstemmed Amidinato Isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
title_sort amidinato isopropylmethylamidosilylene-catalyzed hydroboration of carbonyl compounds
publishDate 2022
url https://hdl.handle.net/10356/163350
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