Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects

• Main Authors: Cao, Ye, Tan, Yang Fei, Wong, Yee Shan, Aminuddin, Muhammad, Ramya, Bhuthalingam, Liew, Melvin Wen Jie, Liu, Jiaxin, Venkatraman, Subbu S.
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Materials; Chitosan; Methacrylic Acid
• Online Access: https://hdl.handle.net/10356/163357
• Institution: Nanyang Technological University

Despite immense revolutionary therapeutics potential, sustaining release of active small interfering RNA (siRNA) remains an arduous challenge. The development of nanoparticles with siRNA sustained release capabilities provides an avenue to enhance the therapeutic efficacy of gene-based therapy. Here...