Enaminone formation drives the coupling of biosynthetic pathways to generate cyclic lipopeptides

• Main Authors: Candra, Hartono, Ma, Guang-Lei, Lee, Sean Qiu En, Liang, Zhao-Xun
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Biological sciences; Biosynthesis; Natural product; Peptide
• 在線閱讀: https://hdl.handle.net/10356/163433

A family of novel cyclic lipopeptides named tasikamides A H (Tsk A H) were discovered recently in Streptomyces tasikensis P46. Aside from the unique cyclic pentapeptide scaffold shared by the tasikamides, Tsk A C contain a hydrazone bridge that connects the cyclic pentapeptide to the lipophil...