Salting-Out crystallization of glycopeptide Vancomycin: phase behavior study to control the crystal habit

• Main Authors: Pu, Siyu, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Protein Crystallization; Crystal Shape
• Online Access: https://hdl.handle.net/10356/163454
• Institution: Nanyang Technological University

Needle-shaped crystals pose downstream processing issues in pharmaceutical manufacturing. Strategies to avoid needle-shaped crystal formation have been developed for small-molecule and protein pharmaceuticals. Controlling crystal habit of peptides, whose molecular weight lies between small molecules...