Guiding irregular nuclear morphology on nanopillar arrays for malignancy differentiation in tumor cells

• Main Authors: Zeng, Yongpeng, Zhuang, Yinyin, Vinod, Benjamin, Guo, Xiangfu, Mitra, Aninda, Chen, Peng, Saggio, Isabella, Shivashankar, G. V., Gao, Weibo, Zhao, Wenting
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Nanopillar; Subnuclear Irregularity
• Online Access: https://hdl.handle.net/10356/163458
• Institution: Nanyang Technological University

For more than a century, abnormal nuclei in tumor cells, presenting subnuclear invaginations and folds on the nuclear envelope, have been known to be associated with high malignancy and poor prognosis. However, current nuclear morphology analysis focuses on the features of the entire nucleus, overlo...