Nuclear omics of mouse forebrain excitatory neurons in pilocarpine-induced seizures

• Main Author: Soon, Hui Rong
• Other Authors: Chng Toh Hean
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2022
• Subjects: Science::Biological sciences::Human anatomy and physiology::Neurobiology; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/163613
• Institution: Nanyang Technological University

An epileptic seizure generates massive neuronal activity in the brain which induces de novo transcription and translation, bringing about cellular changes which may contribute to epileptogenesis. To understand the cell-type-specific molecular changes brought about by seizures, I isolated nuclei from...