Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study

Background: Screening older adults at risk of hospitalization is essential to prevention of this adverse event. Motoric cognitive risk syndrome (MCR) has been associated with incident dementia and falls, which are both risk factors of hospitalization. There is no information on the association of MC...

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Main Authors: Beauchet, Olivier, Matskiv, Jacqueline, Launay, Cyrille P., Gaudreau, Pierrette, Allali, Gilles
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163632
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spelling sg-ntu-dr.10356-1636322023-03-05T16:51:32Z Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study Beauchet, Olivier Matskiv, Jacqueline Launay, Cyrille P. Gaudreau, Pierrette Allali, Gilles Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Cognitive Impairment Cohort Study Background: Screening older adults at risk of hospitalization is essential to prevention of this adverse event. Motoric cognitive risk syndrome (MCR) has been associated with incident dementia and falls, which are both risk factors of hospitalization. There is no information on the association of MCR with incident hospitalization in older adults. Objective: The study aims to examine the association of MCR with incident hospitalization in community-dwelling older adults. Design: Quebec older population-based observational cohort study with 3 years of follow-up. Setting: Community dwellings. Subjects: A subset of 999 participants recruited in the NuAge study. Methods: Participants with MCR (i.e., with slow gait and cognitive complaint without dementia or motor disability) were identified at baseline assessment. Incident hospitalization (i.e., ≥1) and its recurrence (i.e., ≥2) were collected annually over a 3 year follow-up period. Results: The prevalence of MCR was 5.0% at baseline. The overall incidence of hospitalization was 29.0% and its recurrence 4.8%. MCR was associated with incident recurrent hospitalization [adjusted Hazard Ratio (aHR) = 2.58 with 95% Confidence Interval (CI) = (1.09–6.09) and P = 0.031], but not with incident hospitalization [aHR = 1.48, with 95%CI = (0.95–2.28) and P = 0.081]. Conclusion: MCR is associated with incident recurrent hospitalization in NuAge participants, suggesting that MCR may be of clinical interest for screening individuals at risk for hospitalization in Quebec's older population. Published version The NuAge Study was funded by the Canadian Institutes of Health Research (CIHR; MOP-62842). The NuAge Database and Biobank are supported by the Fonds de recherche du Québec (FRQ; 2020-VICO-279753), the Quebec Network for Research on Aging, a thematic network funded by the FRQ-Santé, and by the Merck-Frosst Chair funded by La Fondation de l’Université de Sherbrooke. An access to this research bank can be asked by completing an access request on their website (https://nuage. recherche.usherbrooke.ca/en/). OB and GA were supported by the National Institute of Health/National Institute on Aging grants PO1 AG03949 and R01AG057548-01A1. The French Ministry of Health financially supported the study. The sponsor had no role in designing and conducting the study, nor in the collection, management, analysis, and interpretation of the data, nor in the preparation, review, or approval of the manuscript and writing of the study. 2022-12-13T02:26:00Z 2022-12-13T02:26:00Z 2022 Journal Article Beauchet, O., Matskiv, J., Launay, C. P., Gaudreau, P. & Allali, G. (2022). Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study. Frontiers in Medicine, 9, 930943-. https://dx.doi.org/10.3389/fmed.2022.930943 2296-858X https://hdl.handle.net/10356/163632 10.3389/fmed.2022.930943 36052324 2-s2.0-85136986088 9 930943 en Frontiers in Medicine © 2022 Beauchet, Matskiv, Launay, Gaudreau and Allali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Cognitive Impairment
Cohort Study
spellingShingle Science::Medicine
Cognitive Impairment
Cohort Study
Beauchet, Olivier
Matskiv, Jacqueline
Launay, Cyrille P.
Gaudreau, Pierrette
Allali, Gilles
Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
description Background: Screening older adults at risk of hospitalization is essential to prevention of this adverse event. Motoric cognitive risk syndrome (MCR) has been associated with incident dementia and falls, which are both risk factors of hospitalization. There is no information on the association of MCR with incident hospitalization in older adults. Objective: The study aims to examine the association of MCR with incident hospitalization in community-dwelling older adults. Design: Quebec older population-based observational cohort study with 3 years of follow-up. Setting: Community dwellings. Subjects: A subset of 999 participants recruited in the NuAge study. Methods: Participants with MCR (i.e., with slow gait and cognitive complaint without dementia or motor disability) were identified at baseline assessment. Incident hospitalization (i.e., ≥1) and its recurrence (i.e., ≥2) were collected annually over a 3 year follow-up period. Results: The prevalence of MCR was 5.0% at baseline. The overall incidence of hospitalization was 29.0% and its recurrence 4.8%. MCR was associated with incident recurrent hospitalization [adjusted Hazard Ratio (aHR) = 2.58 with 95% Confidence Interval (CI) = (1.09–6.09) and P = 0.031], but not with incident hospitalization [aHR = 1.48, with 95%CI = (0.95–2.28) and P = 0.081]. Conclusion: MCR is associated with incident recurrent hospitalization in NuAge participants, suggesting that MCR may be of clinical interest for screening individuals at risk for hospitalization in Quebec's older population.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Beauchet, Olivier
Matskiv, Jacqueline
Launay, Cyrille P.
Gaudreau, Pierrette
Allali, Gilles
format Article
author Beauchet, Olivier
Matskiv, Jacqueline
Launay, Cyrille P.
Gaudreau, Pierrette
Allali, Gilles
author_sort Beauchet, Olivier
title Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
title_short Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
title_full Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
title_fullStr Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
title_full_unstemmed Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: results of the NuAge cohort study
title_sort motoric cognitive risk syndrome and incident hospitalization in quebec's older population: results of the nuage cohort study
publishDate 2022
url https://hdl.handle.net/10356/163632
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