Development of SERS tags for human diseases screening and detection
Recent advances in surface-enhanced Raman scattering (SERS) have offered great promise for the early-stage diagnosis of life-threatening diseases by in vivo sensing and imaging techniques as well as a treatment and evaluation of its efficacy. The SERS technique makes use of specially designed tags m...
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sg-ntu-dr.10356-1636372022-12-13T03:12:13Z Development of SERS tags for human diseases screening and detection Gong, Tianxun Das, Chandreyee Manas Yin, Ming-Jie Lv, Tian-Run Singh, Nishtha Manish Soehartono, Alana Mauluidy Singh, Gurvinder An, Quan-Fu Yong, Ken-Tye School of Electrical and Electronic Engineering Engineering::Electrical and electronic engineering Nanoplasmonics Raman Spectroscopy Recent advances in surface-enhanced Raman scattering (SERS) have offered great promise for the early-stage diagnosis of life-threatening diseases by in vivo sensing and imaging techniques as well as a treatment and evaluation of its efficacy. The SERS technique makes use of specially designed tags made up of a metallic nanoparticle, a Raman reporter molecule, a biocompatible protection layer, and a sensing layer, realizing the signal amplification by the electromagnetic enhancement (EE) originating from the plasmon excitation of metal nanostructures and chemical enhancement (CE) owing to chemical interactions and photon-induced charge transfer between the metal and target molecule. These SERS tags have been proven to be a promising candidate for medical applications compared to other conventional techniques because of their high sensitivity, low detection limit, good selectivity, high photostability, low interferences from biological matrices, and multiplexing capabilities. As a result, there has been a surge in the reports for developing SERS tags for molecular diagnostics, immunoassays, biomarker detection, and drug screening applications. Here, we review the recent progress made in the development of SERS tags, including the preparation strategies and properties of SERS tags. The multiple uses of SERS tags in the detection of biomarkers, proteins, cancer and stem cells, cell labeling drug delivery, photothermal therapy, and multimodal imaging techniques have also been reviewed and discussed. Finally, we provide a forward look at how SERS tags may overcome their limitations to guide future SERS tags design with clinical outcomes. This work was supported by the University of Sydney (Startup Grant, Australia) and the National Natural Science Foundation of China (21975005, China). 2022-12-13T03:12:12Z 2022-12-13T03:12:12Z 2022 Journal Article Gong, T., Das, C. M., Yin, M., Lv, T., Singh, N. M., Soehartono, A. M., Singh, G., An, Q. & Yong, K. (2022). Development of SERS tags for human diseases screening and detection. Coordination Chemistry Reviews, 470, 214711-. https://dx.doi.org/10.1016/j.ccr.2022.214711 0010-8545 https://hdl.handle.net/10356/163637 10.1016/j.ccr.2022.214711 2-s2.0-85134359960 470 214711 en Coordination Chemistry Reviews © 2022 Elsevier B.V. All rights reserved. |
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Engineering::Electrical and electronic engineering Nanoplasmonics Raman Spectroscopy Gong, Tianxun Das, Chandreyee Manas Yin, Ming-Jie Lv, Tian-Run Singh, Nishtha Manish Soehartono, Alana Mauluidy Singh, Gurvinder An, Quan-Fu Yong, Ken-Tye Development of SERS tags for human diseases screening and detection |
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Recent advances in surface-enhanced Raman scattering (SERS) have offered great promise for the early-stage diagnosis of life-threatening diseases by in vivo sensing and imaging techniques as well as a treatment and evaluation of its efficacy. The SERS technique makes use of specially designed tags made up of a metallic nanoparticle, a Raman reporter molecule, a biocompatible protection layer, and a sensing layer, realizing the signal amplification by the electromagnetic enhancement (EE) originating from the plasmon excitation of metal nanostructures and chemical enhancement (CE) owing to chemical interactions and photon-induced charge transfer between the metal and target molecule. These SERS tags have been proven to be a promising candidate for medical applications compared to other conventional techniques because of their high sensitivity, low detection limit, good selectivity, high photostability, low interferences from biological matrices, and multiplexing capabilities. As a result, there has been a surge in the reports for developing SERS tags for molecular diagnostics, immunoassays, biomarker detection, and drug screening applications. Here, we review the recent progress made in the development of SERS tags, including the preparation strategies and properties of SERS tags. The multiple uses of SERS tags in the detection of biomarkers, proteins, cancer and stem cells, cell labeling drug delivery, photothermal therapy, and multimodal imaging techniques have also been reviewed and discussed. Finally, we provide a forward look at how SERS tags may overcome their limitations to guide future SERS tags design with clinical outcomes. |
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School of Electrical and Electronic Engineering |
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School of Electrical and Electronic Engineering Gong, Tianxun Das, Chandreyee Manas Yin, Ming-Jie Lv, Tian-Run Singh, Nishtha Manish Soehartono, Alana Mauluidy Singh, Gurvinder An, Quan-Fu Yong, Ken-Tye |
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Article |
author |
Gong, Tianxun Das, Chandreyee Manas Yin, Ming-Jie Lv, Tian-Run Singh, Nishtha Manish Soehartono, Alana Mauluidy Singh, Gurvinder An, Quan-Fu Yong, Ken-Tye |
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Gong, Tianxun |
title |
Development of SERS tags for human diseases screening and detection |
title_short |
Development of SERS tags for human diseases screening and detection |
title_full |
Development of SERS tags for human diseases screening and detection |
title_fullStr |
Development of SERS tags for human diseases screening and detection |
title_full_unstemmed |
Development of SERS tags for human diseases screening and detection |
title_sort |
development of sers tags for human diseases screening and detection |
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2022 |
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https://hdl.handle.net/10356/163637 |
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