In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens
Water polluted by pharmaceutically active compounds (PhACs) and water-borne pathogens urgently need to develop eco-friendly and advanced water treatment techniques. This paper evaluates the potential of using calcium peroxide (CaO2), a safe and biocompatible oxidant both PhACs (thiamphenicol, florfe...
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sg-ntu-dr.10356-1636582022-12-13T06:41:58Z In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens Zheng, Ming Gao, Bing Zhang, Jie El-Din, Mohamed Gamal Snyder, Shane Allen Wu, Minghong Tang, Liang Nanyang Environment and Water Research Institute Engineering::Environmental engineering Calcium Peroxide Pathogenic Microorganisms Water polluted by pharmaceutically active compounds (PhACs) and water-borne pathogens urgently need to develop eco-friendly and advanced water treatment techniques. This paper evaluates the potential of using calcium peroxide (CaO2), a safe and biocompatible oxidant both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. This paper evaluates the potential of using calcium peroxide (CaO2) as a safe and biocompatible oxidant to remove both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. The increased CaO2 dosage increased efficiencies of PhACs attenuation and pathogens inactivation, and both exhibited pseudo-first-order degradation kinetics (R2 > 0.90). PhACs attenuation were mainly via oxidization (H2O2, •OH/O•-, and O2•-) and alkaline hydrolysis (OH-) from CaO2. Moreover, concentrations of these reactive species and their contributions to PhACs attenuation were quantified, and mechanistic model was established and validated. Besides, possible transformation pathways of target PhACs except primidone were proposed. As for pathogen indicators, the suitable inactivation dosage of CaO2 was 0.1 g L-1. The oxidability (18-64%) and alkalinity (82-36%) generated from CaO2 played vital roles in pathogen inactivation. In addition, CaO2 at 0.01-0.1 g L-1 can be applied in remediation of SW contaminated by PhACs and pathogenic bacteria, which can degrade target PhACs with efficiencies of 21-100% under 0.01 g L-1 CaO2, and inactivate 100% of test bacteria under 0.1 g L-1 CaO2. In short, capability of CaO2 to remove target PhACs and microbial pathogens reveals its potential to be used as a representative technology for the advanced treatment of waters contaminated by organic compounds and microbial pathogens. This work was supported by the China Postdoctoral Science Foundation (2020M671067), and Guangdong Basic and Applied Basic Research Foundation (2020A1515110591). 2022-12-13T06:41:58Z 2022-12-13T06:41:58Z 2022 Journal Article Zheng, M., Gao, B., Zhang, J., El-Din, M. G., Snyder, S. A., Wu, M. & Tang, L. (2022). In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens. Environmental Research, 212(Part D), 113531-. https://dx.doi.org/10.1016/j.envres.2022.113531 0013-9351 https://hdl.handle.net/10356/163658 10.1016/j.envres.2022.113531 35613632 2-s2.0-85131375476 Part D 212 113531 en Environmental Research © 2022 Elsevier Inc. All rights reserved. |
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Engineering::Environmental engineering Calcium Peroxide Pathogenic Microorganisms Zheng, Ming Gao, Bing Zhang, Jie El-Din, Mohamed Gamal Snyder, Shane Allen Wu, Minghong Tang, Liang In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
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Water polluted by pharmaceutically active compounds (PhACs) and water-borne pathogens urgently need to develop eco-friendly and advanced water treatment techniques. This paper evaluates the potential of using calcium peroxide (CaO2), a safe and biocompatible oxidant both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. This paper evaluates the potential of using calcium peroxide (CaO2) as a safe and biocompatible oxidant to remove both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. The increased CaO2 dosage increased efficiencies of PhACs attenuation and pathogens inactivation, and both exhibited pseudo-first-order degradation kinetics (R2 > 0.90). PhACs attenuation were mainly via oxidization (H2O2, •OH/O•-, and O2•-) and alkaline hydrolysis (OH-) from CaO2. Moreover, concentrations of these reactive species and their contributions to PhACs attenuation were quantified, and mechanistic model was established and validated. Besides, possible transformation pathways of target PhACs except primidone were proposed. As for pathogen indicators, the suitable inactivation dosage of CaO2 was 0.1 g L-1. The oxidability (18-64%) and alkalinity (82-36%) generated from CaO2 played vital roles in pathogen inactivation. In addition, CaO2 at 0.01-0.1 g L-1 can be applied in remediation of SW contaminated by PhACs and pathogenic bacteria, which can degrade target PhACs with efficiencies of 21-100% under 0.01 g L-1 CaO2, and inactivate 100% of test bacteria under 0.1 g L-1 CaO2. In short, capability of CaO2 to remove target PhACs and microbial pathogens reveals its potential to be used as a representative technology for the advanced treatment of waters contaminated by organic compounds and microbial pathogens. |
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Nanyang Environment and Water Research Institute |
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Nanyang Environment and Water Research Institute Zheng, Ming Gao, Bing Zhang, Jie El-Din, Mohamed Gamal Snyder, Shane Allen Wu, Minghong Tang, Liang |
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Article |
author |
Zheng, Ming Gao, Bing Zhang, Jie El-Din, Mohamed Gamal Snyder, Shane Allen Wu, Minghong Tang, Liang |
author_sort |
Zheng, Ming |
title |
In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
title_short |
In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
title_full |
In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
title_fullStr |
In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
title_full_unstemmed |
In-situ chemical attenuation of pharmaceutically active compounds using CaO₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
title_sort |
in-situ chemical attenuation of pharmaceutically active compounds using cao₂: influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens |
publishDate |
2022 |
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https://hdl.handle.net/10356/163658 |
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1753801177433112576 |