Development of an online monitoring system for the control of continuous chromatographic separation

The current use of ultraviolet (UV) detector and polarimeter in series for the online monitoring of continuous chromatographic process has resulted in various problems in data accuracy, data reproducibility as well as the system stability. In order to overcome these shortcomings, a novel online moni...

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Main Author: Nguyen, Trong Tan.
Other Authors: Mohammad Aman Ullah
Format: Final Year Project
Language:English
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10356/16380
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-163802023-03-03T15:41:32Z Development of an online monitoring system for the control of continuous chromatographic separation Nguyen, Trong Tan. Mohammad Aman Ullah School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry::Analytical chemistry::Chromatography The current use of ultraviolet (UV) detector and polarimeter in series for the online monitoring of continuous chromatographic process has resulted in various problems in data accuracy, data reproducibility as well as the system stability. In order to overcome these shortcomings, a novel online monitoring system that utilizes an analytical High Performance Liquid Chromatography (HPLC) column with UV detector as sensor is proposed in this work. The use of HPLC may result in lower frequency concentration analysis but guarantees the accuracy and reliability of analyzed data. The proposed monitoring system is constructed based on results obtained from simulation of a continuous single-column-with-periodic recycling chromatographic process used for chiral separation of Guaifenesin. The model was mathematically solved by applying finite difference method and was successfully implemented in Matlab. Though built on a single column model, this system, if successfully implemented, is expected to be applicable in all configurations of continuous chromatographic separation process, or the Simulated Moving Bed process in specific. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-25T09:19:24Z 2009-05-25T09:19:24Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16380 en Nanyang Technological University 67 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Analytical chemistry::Chromatography
spellingShingle DRNTU::Science::Chemistry::Analytical chemistry::Chromatography
Nguyen, Trong Tan.
Development of an online monitoring system for the control of continuous chromatographic separation
description The current use of ultraviolet (UV) detector and polarimeter in series for the online monitoring of continuous chromatographic process has resulted in various problems in data accuracy, data reproducibility as well as the system stability. In order to overcome these shortcomings, a novel online monitoring system that utilizes an analytical High Performance Liquid Chromatography (HPLC) column with UV detector as sensor is proposed in this work. The use of HPLC may result in lower frequency concentration analysis but guarantees the accuracy and reliability of analyzed data. The proposed monitoring system is constructed based on results obtained from simulation of a continuous single-column-with-periodic recycling chromatographic process used for chiral separation of Guaifenesin. The model was mathematically solved by applying finite difference method and was successfully implemented in Matlab. Though built on a single column model, this system, if successfully implemented, is expected to be applicable in all configurations of continuous chromatographic separation process, or the Simulated Moving Bed process in specific.
author2 Mohammad Aman Ullah
author_facet Mohammad Aman Ullah
Nguyen, Trong Tan.
format Final Year Project
author Nguyen, Trong Tan.
author_sort Nguyen, Trong Tan.
title Development of an online monitoring system for the control of continuous chromatographic separation
title_short Development of an online monitoring system for the control of continuous chromatographic separation
title_full Development of an online monitoring system for the control of continuous chromatographic separation
title_fullStr Development of an online monitoring system for the control of continuous chromatographic separation
title_full_unstemmed Development of an online monitoring system for the control of continuous chromatographic separation
title_sort development of an online monitoring system for the control of continuous chromatographic separation
publishDate 2009
url http://hdl.handle.net/10356/16380
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