An update on adrenocortical cell lines of human origin
Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease. Management of ACC is dependent on disease stage with complete surgical resection as the only potentially curative option. However, advanced, un-resectable, metastatic stages and also recurrences often require system...
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sg-ntu-dr.10356-1638492023-03-05T16:52:43Z An update on adrenocortical cell lines of human origin Sigala, Sandra Rossini, Elisa Abate, Andrea Tamburello, Mariangela Bornstein, Stefan R. Hantel, Constanze Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Adrenal Cortex Carcinoma Adrenal Cortex Tumor Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease. Management of ACC is dependent on disease stage with complete surgical resection as the only potentially curative option. However, advanced, un-resectable, metastatic stages and also recurrences often require systemic treatments, which are unfortunately nowadays still unsatisfactory. The scarcity of preclinical models reflecting patient heterogeneities and furthermore drug-resistant phenotypes, has hampered the progress and development of new therapies in recent years. In this review, we provide an overview on the classical models and substantial progress which has been made over the last years in context of this aggressive disease. Published version Open access funding provided by University of Zurich. 2022-12-20T02:15:02Z 2022-12-20T02:15:02Z 2022 Journal Article Sigala, S., Rossini, E., Abate, A., Tamburello, M., Bornstein, S. R. & Hantel, C. (2022). An update on adrenocortical cell lines of human origin. Endocrine, 77(3), 432-437. https://dx.doi.org/10.1007/s12020-022-03112-w 1355-008X https://hdl.handle.net/10356/163849 10.1007/s12020-022-03112-w 35764904 2-s2.0-85133088196 3 77 432 437 en Endocrine © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. application/pdf |
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Science::Medicine Adrenal Cortex Carcinoma Adrenal Cortex Tumor Sigala, Sandra Rossini, Elisa Abate, Andrea Tamburello, Mariangela Bornstein, Stefan R. Hantel, Constanze An update on adrenocortical cell lines of human origin |
| description |
Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease. Management of ACC is dependent on disease stage with complete surgical resection as the only potentially curative option. However, advanced, un-resectable, metastatic stages and also recurrences often require systemic treatments, which are unfortunately nowadays still unsatisfactory. The scarcity of preclinical models reflecting patient heterogeneities and furthermore drug-resistant phenotypes, has hampered the progress and development of new therapies in recent years. In this review, we provide an overview on the classical models and substantial progress which has been made over the last years in context of this aggressive disease. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Sigala, Sandra Rossini, Elisa Abate, Andrea Tamburello, Mariangela Bornstein, Stefan R. Hantel, Constanze |
| format |
Article |
| author |
Sigala, Sandra Rossini, Elisa Abate, Andrea Tamburello, Mariangela Bornstein, Stefan R. Hantel, Constanze |
| author_sort |
Sigala, Sandra |
| title |
An update on adrenocortical cell lines of human origin |
| title_short |
An update on adrenocortical cell lines of human origin |
| title_full |
An update on adrenocortical cell lines of human origin |
| title_fullStr |
An update on adrenocortical cell lines of human origin |
| title_full_unstemmed |
An update on adrenocortical cell lines of human origin |
| title_sort |
update on adrenocortical cell lines of human origin |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/163849 |
| _version_ |
1759853757102817280 |