Genetic risk score for plasma uric acid levels is associated with early rapid kidney function decline in type 2 diabetes

• Main Authors: Gurung, Resham Lal, Yiamunaa, M., Liu, Jian-Jun, Dorajoo, Rajkumar, Wang, Jiexun, Wang, Ling, Liu, Sylvia, Chan, Clara, Ang, Keven, Shao, Yi-Ming, Subramaniam, Tavintharan, Tang, Wern E., Sum, Chee Fang, Lim, Su Chi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Uric Acid; Genetic Risk Score
• Online Access: https://hdl.handle.net/10356/163889
• Institution: Nanyang Technological University

Context: Observational studies have shown that elevated uric acid (UA) is associated with chronic kidney disease (CKD). However, whether the relationship is causal remains unclear. Objective: To determine the association of plasma UA and incident CKD and the causal relationship between plasma UA and...