Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation
Green delivery carriers of nanopesticides, like sophorolipid biosurfactants, are of great significance to reduce environmental pollution and promote sustainable agricultural development. However, the molecular diversity of an unisolated sophorolipid mixture with almost unpredictable self-assembly pr...
Saved in:
Main Authors: | , , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/163917 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-163917 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1639172022-12-22T00:54:22Z Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation Ma, Enguang Chen, Kai Sun, Liang Fu, Zhinan Guo, Jiangtao Liu, Jichang Zhao, Jigang Liu, Zhiyong Lei, Zhigang Li, Li Hu, Xiao Guo, Xuhong School of Materials Science and Engineering Engineering::Chemical engineering Pesticide Biosurfactant Green delivery carriers of nanopesticides, like sophorolipid biosurfactants, are of great significance to reduce environmental pollution and promote sustainable agricultural development. However, the molecular diversity of an unisolated sophorolipid mixture with almost unpredictable self-assembly properties has limited the in-depth study of its structure-activity relationship and hindered the development of green pesticide delivery systems. In this work, the acidic and lactonic sophorolipids were successfully separated from the sophorolipid mixture through silica gel column chromatography. A series of cost-effective green nanopesticides loaded with lambda-cyhalothrin (LC) were rapidly fabricated based on a combination of the acidic and lactonic sophorolipids as surfactants by flash nanoprecipitation. The effects of the acidic-to-lactonic ratio on particle size, drug loading capacity, and biological activity against Hyphantria cunea of LC-loaded nanoparticles were systematically investigated. The resultant nanopesticides exhibited a better insecticidal efficacy than a commercial emulsifiable concentrate formulation. This work opens up a novel strategy to construct scalable, cost-effective, and environmentally friendly nanopesticide systems. We acknowledge financial support from the National Natural Science Foundation of China (Grant 51773061), China Henan Kaifeng PingMei ShenMa Xinghua Fine Chemical Co., Ltd., and the Start-Up Foundation for High-level Professionals of Shihezi University (RCZK2021B07). 2022-12-22T00:54:21Z 2022-12-22T00:54:21Z 2022 Journal Article Ma, E., Chen, K., Sun, L., Fu, Z., Guo, J., Liu, J., Zhao, J., Liu, Z., Lei, Z., Li, L., Hu, X. & Guo, X. (2022). Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation. Journal of Agricultural and Food Chemistry, 70(16), 4912-4920. https://dx.doi.org/10.1021/acs.jafc.2c00743 0021-8561 https://hdl.handle.net/10356/163917 10.1021/acs.jafc.2c00743 35417168 2-s2.0-85128689255 16 70 4912 4920 en Journal of Agricultural and Food Chemistry © 2022 American Chemical Society. All rights reserved. |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Engineering::Chemical engineering Pesticide Biosurfactant |
spellingShingle |
Engineering::Chemical engineering Pesticide Biosurfactant Ma, Enguang Chen, Kai Sun, Liang Fu, Zhinan Guo, Jiangtao Liu, Jichang Zhao, Jigang Liu, Zhiyong Lei, Zhigang Li, Li Hu, Xiao Guo, Xuhong Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
description |
Green delivery carriers of nanopesticides, like sophorolipid biosurfactants, are of great significance to reduce environmental pollution and promote sustainable agricultural development. However, the molecular diversity of an unisolated sophorolipid mixture with almost unpredictable self-assembly properties has limited the in-depth study of its structure-activity relationship and hindered the development of green pesticide delivery systems. In this work, the acidic and lactonic sophorolipids were successfully separated from the sophorolipid mixture through silica gel column chromatography. A series of cost-effective green nanopesticides loaded with lambda-cyhalothrin (LC) were rapidly fabricated based on a combination of the acidic and lactonic sophorolipids as surfactants by flash nanoprecipitation. The effects of the acidic-to-lactonic ratio on particle size, drug loading capacity, and biological activity against Hyphantria cunea of LC-loaded nanoparticles were systematically investigated. The resultant nanopesticides exhibited a better insecticidal efficacy than a commercial emulsifiable concentrate formulation. This work opens up a novel strategy to construct scalable, cost-effective, and environmentally friendly nanopesticide systems. |
author2 |
School of Materials Science and Engineering |
author_facet |
School of Materials Science and Engineering Ma, Enguang Chen, Kai Sun, Liang Fu, Zhinan Guo, Jiangtao Liu, Jichang Zhao, Jigang Liu, Zhiyong Lei, Zhigang Li, Li Hu, Xiao Guo, Xuhong |
format |
Article |
author |
Ma, Enguang Chen, Kai Sun, Liang Fu, Zhinan Guo, Jiangtao Liu, Jichang Zhao, Jigang Liu, Zhiyong Lei, Zhigang Li, Li Hu, Xiao Guo, Xuhong |
author_sort |
Ma, Enguang |
title |
Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
title_short |
Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
title_full |
Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
title_fullStr |
Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
title_full_unstemmed |
Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
title_sort |
rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation |
publishDate |
2022 |
url |
https://hdl.handle.net/10356/163917 |
_version_ |
1753801184255148032 |