Bruton's tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids

Bruton's tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids

The Ras-GTPase activating protein SH3 domain-binding protein 1 (G3BP1) plays a critical role in the formation of classical and antiviral stress granules in stressed and virus-infected eukaryotic cells, respectively. While G3BP1 is known to be phosphorylated at serine residues which could affect stre...

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Bibliographic Details
Main Authors: Kim, Susana S-Y., Sim, Don C. N., Carissimo, Guillaume, Lim, Hong-Hwa, Lam, Kong-Peng
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Endoribonuclease G3BP
Rasputin
Online Access:https://hdl.handle.net/10356/163921
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/163921

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