Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold

• Main Authors: Cheong, Ezekiel Ze Ken, Quek, Jun-Ping, Xin, Liu, Li, Chaoqiang, Chan, Jing Yi, Liew, Chong Wai, Mu, Yuguang, Zheng, Jie, Luo, Dahai
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Medicine; Rubella Virus; Antiviral Therapeutics
• 在線閱讀: https://hdl.handle.net/10356/163922
• 機構: Nanyang Technological University

Rubella, a viral disease characterized by a red skin rash, is well controlled because of an effective vaccine, but outbreaks are still occurring in the absence of available antiviral treatments. The Rubella virus (RUBV) papain-like protease (RubPro) is crucial for RUBV replication, cleaving the nons...