Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold

• المؤلفون الرئيسيون: Cheong, Ezekiel Ze Ken, Quek, Jun-Ping, Xin, Liu, Li, Chaoqiang, Chan, Jing Yi, Liew, Chong Wai, Mu, Yuguang, Zheng, Jie, Luo, Dahai
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Medicine; Rubella Virus; Antiviral Therapeutics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163922
• المؤسسة: Nanyang Technological University

Rubella, a viral disease characterized by a red skin rash, is well controlled because of an effective vaccine, but outbreaks are still occurring in the absence of available antiviral treatments. The Rubella virus (RUBV) papain-like protease (RubPro) is crucial for RUBV replication, cleaving the nons...