Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

• Main Authors: Zhang, Qian, Matuozzo, Daniela, Le Pen, Jérémie, Lee, Danyel, Moens, Leen, Asano, Takaki, Bohlen, Jonathan, Liu, Zhiyong, Moncada-Velez, Marcela, Kendir-Demirkol, Yasemin, Jing, Huie, Bizien, Lucy, Marchal, Astrid, Abolhassani, Hassan, Delafontaine, Selket, Bucciol, Giorgia, Bayhan, Gulsum Ical, Keles, Sevgi, Kiykim, Ayca, Hancerli, Selda, Haerynck, Filomeen, Florkin, Benoit, Hatipoglu, Nevin, Ozcelik, Tayfun, Morelle, Guillaume, Zatz, Mayana, Ng, Lisa F. P., Lye, David C., Young, Barnaby Edward, Leo, Yee Sin, Dalgard, Clifton L., Lifton, Richard P., Renia, Laurent, Meyts, Isabelle, Jouanguy, Emmanuelle, Hammarström, Lennart, Pan-Hammarström, Qiang, Boisson, Bertrand, Bastard, Paul, Su, Helen C., Boisson-Dupuis, Stéphanie, Abel, Laurent, Rice, Charles M., Zhang, Shen-Ying, Cobat, Aurélie, Casanova, Jean-Laurent
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Pyogenic Bacterial-Infections; Simplex-Virus Encephalitis
• Online Access: https://hdl.handle.net/10356/163940
• Institution: Nanyang Technological University

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 ch...