Fabrication of carbon fibre microelectrode array for neural recording
Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its...
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sg-ntu-dr.10356-1640082023-03-04T20:15:58Z Fabrication of carbon fibre microelectrode array for neural recording Ng, Nicholas Tse Jian Hirotaka Sato School of Mechanical and Aerospace Engineering hirosato@ntu.edu.sg Engineering::Mechanical engineering::Bio-mechatronics Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its chemical and physical properties. This objective of this project is to develop and evaluate multichannel carbon fibre microelectrode array (MEA) for long-time in-vivo neural recording. Firstly, carbon fibres are assessed on their suitability as a microelectrode. The electrical impedance, Z, of the carbon fibre microelectrode must be less than 2MΩ when subjected to an electrical current of 1khz. Afterwards, several methods of insulating the carbon fibres were conducted and evaluated: isolation through 3d printed housing, insulation with polyimide tubing, insulation with nail polish, anodic electrophoretic deposition. In the final design of the microelectrode array, anodic electrophoretic deposition is chosen. The assembly of the microelectrode involves the incorporation of 3d printed parts and the processed carbon fibres. The microelectrode array is implanted in the brain of the Madagascar Hissing Cockroach and evaluated to be satisfactory in its recording capability. Documented with the use of intan RHX recording equipment. Improvements via experimental verification such as SEM imaging are suggested to improve the signal-to-noise ratio and quality of signal recording of the microelectrode array. Bachelor of Engineering (Mechanical Engineering) 2023-01-03T07:35:42Z 2023-01-03T07:35:42Z 2022 Final Year Project (FYP) Ng, N. T. J. (2022). Fabrication of carbon fibre microelectrode array for neural recording. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/164008 https://hdl.handle.net/10356/164008 en B395 application/pdf Nanyang Technological University |
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Engineering::Mechanical engineering::Bio-mechatronics Ng, Nicholas Tse Jian Fabrication of carbon fibre microelectrode array for neural recording |
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Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its chemical and physical properties. This objective of this project is to develop and evaluate multichannel carbon fibre microelectrode array (MEA) for long-time in-vivo neural recording.
Firstly, carbon fibres are assessed on their suitability as a microelectrode. The electrical impedance, Z, of the carbon fibre microelectrode must be less than 2MΩ when subjected to an electrical current of 1khz. Afterwards, several methods of insulating the carbon fibres were conducted and evaluated: isolation through 3d printed housing, insulation with polyimide tubing, insulation with nail polish, anodic electrophoretic deposition. In the final design of the microelectrode array, anodic electrophoretic deposition is chosen. The assembly of the microelectrode involves the incorporation of 3d printed parts and the processed carbon fibres. The microelectrode array is implanted in the brain of the Madagascar Hissing Cockroach and evaluated to be satisfactory in its recording capability. Documented with the use of intan RHX recording equipment. Improvements via experimental verification such as SEM imaging are suggested to improve the signal-to-noise ratio and quality of signal recording of the microelectrode array. |
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Hirotaka Sato |
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Hirotaka Sato Ng, Nicholas Tse Jian |
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Final Year Project |
author |
Ng, Nicholas Tse Jian |
author_sort |
Ng, Nicholas Tse Jian |
title |
Fabrication of carbon fibre microelectrode array for neural recording |
title_short |
Fabrication of carbon fibre microelectrode array for neural recording |
title_full |
Fabrication of carbon fibre microelectrode array for neural recording |
title_fullStr |
Fabrication of carbon fibre microelectrode array for neural recording |
title_full_unstemmed |
Fabrication of carbon fibre microelectrode array for neural recording |
title_sort |
fabrication of carbon fibre microelectrode array for neural recording |
publisher |
Nanyang Technological University |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/164008 |
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1759855342175387648 |