Fabrication of carbon fibre microelectrode array for neural recording

Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its...

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Main Author: Ng, Nicholas Tse Jian
Other Authors: Hirotaka Sato
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/164008
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1640082023-03-04T20:15:58Z Fabrication of carbon fibre microelectrode array for neural recording Ng, Nicholas Tse Jian Hirotaka Sato School of Mechanical and Aerospace Engineering hirosato@ntu.edu.sg Engineering::Mechanical engineering::Bio-mechatronics Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its chemical and physical properties. This objective of this project is to develop and evaluate multichannel carbon fibre microelectrode array (MEA) for long-time in-vivo neural recording. Firstly, carbon fibres are assessed on their suitability as a microelectrode. The electrical impedance, Z, of the carbon fibre microelectrode must be less than 2MΩ when subjected to an electrical current of 1khz. Afterwards, several methods of insulating the carbon fibres were conducted and evaluated: isolation through 3d printed housing, insulation with polyimide tubing, insulation with nail polish, anodic electrophoretic deposition. In the final design of the microelectrode array, anodic electrophoretic deposition is chosen. The assembly of the microelectrode involves the incorporation of 3d printed parts and the processed carbon fibres. The microelectrode array is implanted in the brain of the Madagascar Hissing Cockroach and evaluated to be satisfactory in its recording capability. Documented with the use of intan RHX recording equipment. Improvements via experimental verification such as SEM imaging are suggested to improve the signal-to-noise ratio and quality of signal recording of the microelectrode array. Bachelor of Engineering (Mechanical Engineering) 2023-01-03T07:35:42Z 2023-01-03T07:35:42Z 2022 Final Year Project (FYP) Ng, N. T. J. (2022). Fabrication of carbon fibre microelectrode array for neural recording. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/164008 https://hdl.handle.net/10356/164008 en B395 application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Mechanical engineering::Bio-mechatronics
spellingShingle Engineering::Mechanical engineering::Bio-mechatronics
Ng, Nicholas Tse Jian
Fabrication of carbon fibre microelectrode array for neural recording
description Microelectrodes are unique electrodes used to study the electrical activity of individual biological cells. Currently microelectrodes are conventionally made with glass or metal. However, these materials are harmful to living organisms. Carbon fibres are more harmless to living organisms due to its chemical and physical properties. This objective of this project is to develop and evaluate multichannel carbon fibre microelectrode array (MEA) for long-time in-vivo neural recording. Firstly, carbon fibres are assessed on their suitability as a microelectrode. The electrical impedance, Z, of the carbon fibre microelectrode must be less than 2MΩ when subjected to an electrical current of 1khz. Afterwards, several methods of insulating the carbon fibres were conducted and evaluated: isolation through 3d printed housing, insulation with polyimide tubing, insulation with nail polish, anodic electrophoretic deposition. In the final design of the microelectrode array, anodic electrophoretic deposition is chosen. The assembly of the microelectrode involves the incorporation of 3d printed parts and the processed carbon fibres. The microelectrode array is implanted in the brain of the Madagascar Hissing Cockroach and evaluated to be satisfactory in its recording capability. Documented with the use of intan RHX recording equipment. Improvements via experimental verification such as SEM imaging are suggested to improve the signal-to-noise ratio and quality of signal recording of the microelectrode array.
author2 Hirotaka Sato
author_facet Hirotaka Sato
Ng, Nicholas Tse Jian
format Final Year Project
author Ng, Nicholas Tse Jian
author_sort Ng, Nicholas Tse Jian
title Fabrication of carbon fibre microelectrode array for neural recording
title_short Fabrication of carbon fibre microelectrode array for neural recording
title_full Fabrication of carbon fibre microelectrode array for neural recording
title_fullStr Fabrication of carbon fibre microelectrode array for neural recording
title_full_unstemmed Fabrication of carbon fibre microelectrode array for neural recording
title_sort fabrication of carbon fibre microelectrode array for neural recording
publisher Nanyang Technological University
publishDate 2023
url https://hdl.handle.net/10356/164008
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