NMR structure and localization of the host defense peptide thanatinM21F in zwitterionic dodecylphosphocholine micelle: implications in antimicrobial and hemolytic activity

• Main Authors: Sinha, Sheetal, Bhattacharjya, Surajit
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Antimicrobial Peptide; Thanatin
• Online Access: https://hdl.handle.net/10356/164026
• Institution: Nanyang Technological University

Non-hemolytic antimicrobial peptides (AMPs) are vital lead molecules for the designing and development of peptide-based antibiotics. Thanatin a 21-amino acid long single disulfide bonded AMP is known to be highly non-hemolytic with a limited toxicity to human cells and model animals. Thanatin demons...