Columnar structure of human telomeric chromatin

• Main Authors: Soman, Aghil, Wong, Sook Yi, Korolev, Nikolay, Surya, Wahyu, Lattmann, Simon, Vogirala, Vinod Kumar, Chen, Qinming, Berezhnoy, Nikolay V., van Noort, John, Rhodes, Daniela, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Molecule Force Spectroscopy; Nucleosome Core Particle
• Online Access: https://hdl.handle.net/10356/164083
• Institution: Nanyang Technological University

Telomeres, the ends of eukaryotic chromosomes, play pivotal parts in ageing and cancer and are targets of DNA damage and the DNA damage response1-5. Little is known about the structure of telomeric chromatin at the molecular level. Here we used negative stain electron microscopy and single-molecule...