Aqueous outflow channels and its lymphatic association: a review

The human eye has a unique immune architecture and behavior. While the conjunctiva is known to have a well-defined lymphatic drainage system, the cornea, sclera, and uveal tissues were historically considered "alymphatic" and thought to be immune privileged. The very fact that the aqueous...

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Main Authors: Narayanaswamy, Arun, Thakur, Sahil, Nongpiur, Monisha E., Schmetterer, Leopold, Hong, Young-Kwon, Huang, Alex S., Wong, Tina T.
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164133
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1641332023-06-21T07:34:49Z Aqueous outflow channels and its lymphatic association: a review Narayanaswamy, Arun Thakur, Sahil Nongpiur, Monisha E. Schmetterer, Leopold Hong, Young-Kwon Huang, Alex S. Wong, Tina T. School of Chemistry, Chemical Engineering and Biotechnology Singapore Eye Research Institute Duke-NUS Medical School SERI-NTU Advanced Ocular Engineering Programme Science::Medicine Aqueous Humor Glaucoma The human eye has a unique immune architecture and behavior. While the conjunctiva is known to have a well-defined lymphatic drainage system, the cornea, sclera, and uveal tissues were historically considered "alymphatic" and thought to be immune privileged. The very fact that the aqueous outflow channels carry a clear fluid (aqueous humor) along the outflow pathway makes it hard to ignore its lymphatic-like characteristics. The development of novel lymphatic lineage markers and expression of these markers in aqueous outflow channels and improved imaging capabilities has sparked a renewed interest in the study of ocular lymphatics. Ophthalmic lymphatic research has had a directional shift over the last decade, offering an exciting new physiological platform that needs further in-depth understanding. The evidence of a presence of distinct lymphatic channels in the human ciliary body is gaining significant traction. The uveolymphatic pathway is an alternative new route for aqueous outflow and adds a new dimension to pathophysiology and management of glaucoma. Developing novel animal models, markers, and non-invasive imaging tools to delineate the core anatomical structure and physiological functions may help pave some crucial pathways to understand disease pathophysiology and help develop novel targeted therapeutic approaches for glaucoma. Agency for Science, Technology and Research (A*STAR) National Medical Research Council (NMRC) National Research Foundation (NRF) Funding for this work came from the National Institutes of Health, Bethesda, MD (grant numbers R01EY030501 [ASH] and R21EY026260 [YKH]); the Duke-NUS Medical School (DukeNUS-KP(Coll)/2018/0009A), the National Medical Research Council (CG/C010A/2017, OFIRG/0048/2017, OFLCG/004c/2018, and TA/MOH-000249-00/2018), National Research Foundation Singapore, A∗STAR (A20H4b0141), the Singapore Eye Research Institute & Nanyang Technological University (SERI-NTU Advanced Ocular Engineering (STANCE) Program), the SERI-Lee Foundation (LF1019-1) Singapore, Glaucoma Research Foundation Shaffer Grant [ASH], and an unrestricted grant from Research to Prevent Blindness [UCLA] (New York, NY). 2023-01-05T08:47:11Z 2023-01-05T08:47:11Z 2022 Journal Article Narayanaswamy, A., Thakur, S., Nongpiur, M. E., Schmetterer, L., Hong, Y., Huang, A. S. & Wong, T. T. (2022). Aqueous outflow channels and its lymphatic association: a review. Survey of Ophthalmology, 67(3), 659-674. https://dx.doi.org/10.1016/j.survophthal.2021.10.004 0039-6257 https://hdl.handle.net/10356/164133 10.1016/j.survophthal.2021.10.004 34656556 2-s2.0-85119986728 3 67 659 674 en DukeNUS-KP(Coll)/2018/0009A A20H4b0141 LF1019-1 CG/C010A/2017 OFIRG/0048/2017 OFLCG/004c/2018 TA/MOH-000249-00/2018 Survey of Ophthalmology © 2021 Elsevier Inc. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Aqueous Humor
Glaucoma
spellingShingle Science::Medicine
Aqueous Humor
Glaucoma
Narayanaswamy, Arun
Thakur, Sahil
Nongpiur, Monisha E.
Schmetterer, Leopold
Hong, Young-Kwon
Huang, Alex S.
Wong, Tina T.
Aqueous outflow channels and its lymphatic association: a review
description The human eye has a unique immune architecture and behavior. While the conjunctiva is known to have a well-defined lymphatic drainage system, the cornea, sclera, and uveal tissues were historically considered "alymphatic" and thought to be immune privileged. The very fact that the aqueous outflow channels carry a clear fluid (aqueous humor) along the outflow pathway makes it hard to ignore its lymphatic-like characteristics. The development of novel lymphatic lineage markers and expression of these markers in aqueous outflow channels and improved imaging capabilities has sparked a renewed interest in the study of ocular lymphatics. Ophthalmic lymphatic research has had a directional shift over the last decade, offering an exciting new physiological platform that needs further in-depth understanding. The evidence of a presence of distinct lymphatic channels in the human ciliary body is gaining significant traction. The uveolymphatic pathway is an alternative new route for aqueous outflow and adds a new dimension to pathophysiology and management of glaucoma. Developing novel animal models, markers, and non-invasive imaging tools to delineate the core anatomical structure and physiological functions may help pave some crucial pathways to understand disease pathophysiology and help develop novel targeted therapeutic approaches for glaucoma.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Narayanaswamy, Arun
Thakur, Sahil
Nongpiur, Monisha E.
Schmetterer, Leopold
Hong, Young-Kwon
Huang, Alex S.
Wong, Tina T.
format Article
author Narayanaswamy, Arun
Thakur, Sahil
Nongpiur, Monisha E.
Schmetterer, Leopold
Hong, Young-Kwon
Huang, Alex S.
Wong, Tina T.
author_sort Narayanaswamy, Arun
title Aqueous outflow channels and its lymphatic association: a review
title_short Aqueous outflow channels and its lymphatic association: a review
title_full Aqueous outflow channels and its lymphatic association: a review
title_fullStr Aqueous outflow channels and its lymphatic association: a review
title_full_unstemmed Aqueous outflow channels and its lymphatic association: a review
title_sort aqueous outflow channels and its lymphatic association: a review
publishDate 2023
url https://hdl.handle.net/10356/164133
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